Rosuvastatin Calcium & Aspirin (Ec) Capsules

Rosuvastatin calcium 20 mg & Aspirin (EC) 75 mg Capsules

The combination of rosuvastatin and aspirin is used to prevent heart attacks and strokes.

Mechanism of action of Aspirin + Rosuvastatin

• Aspirin is an antiplatelet agent that works by inhibiting platelet aggregation and preventing thrombus formation.
• Rosuvastatin is HMG-CoA reductase inhibitor, an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a critical and rate-limiting step in cholesterol biosynthesis. The mechanism of rosuvastatin leads to cholesterol decrease by increasing the number of low-density lipoprotein (LDL) receptors on the cell surface, hence improving the uptake and catabolism of LDL.

Uses of Aspirin + Rosuvastatin

• Myocardial infarction (heart attack), stroke, or peripheral vascular disease are prevented with the use of aspirin and rosuvastatin. It is classified as an anticholesterol and antilipemic drug that is administered for primary prevention in patients with coronary heart disease who are at high risk for cardiovascular illness.
• It functions both as a blood-thinning medication and a cholesterol-lowering medication, quite effectively lowering the risk of major cardiovascular events.

Side effects of Aspirin + Rosuvastatin

• Abdominal pain
• Indigestion
• Weakness
• Headache
• Nausea
• Diarrhoea

Expert Advice

Dosage Forms Available

• Rosuvastatin and aspirin may be administered orally (capsules, tablets).

Age and Dose Restrictions

• This drug is intended for adults and children older than 16 years.

Contraindications

• People who are known to be allergic to aspirin or who have asthma, as well as significant renal or hepatic illness, should not use aspirin + rosuvastatin or rosuvastatin alone.

Missed Dose and Overdose

• An overdose of this combination can cause headaches, disorientation, and dizziness. Act accordingly and tell your doctor about any such consequences.
• Take this combination as soon as you remember if you’ve missed a dose. But don’t administer the same dosage again.

Other Medications To Avoid With This Medicine

• Other Drugs to Avoid While Taking This Medication. With Aspirin + Rosuvastatin, it is not advised to use any blood thinners (warfarin), gout treatments (probenecid), cancer or anti-arthritis medications (methotrexate), anti-platelet medications (clopidogrel), antidepressants (lithium, sertraline), immunological drugs (cyclosporine, tacrolimus), anti-epileptic drugs (valproate, phenytoin), painkillers (naproxen, ibuprofen), diabetes drugs (insulin glargine), blood pressure drugs (lisinopril), cholesterol-lowering drugs (fenofibrate), antacids, or oral contraceptives.
• Before taking any prescription or over-the-counter medicines, it is crucial to consult your physician.

Use In Driving And Operating Machinery

• Your ability to drive or operate heavy equipment won’t be negatively impacted by this combination. Avoid driving or using heavy machinery if this combination makes you feel dizzy.

Use in Pregnancy and Lactation

• Aspirin + Rosuvastatin is not indicated during pregnancy or lactation.

Special Dietary & Lifestyle Recommendation

• When using aspirin and rosuvastatin, avoid drinking alcohol.
• Patients with a history of heart disease must look at lifestyle changes, including diet modification like taking a low-carbohydrate and low-fat diet along with Aspirin + Rosuvastatin.